منابع مشابه
uPARAP Function in Cutaneous Wound Repair
Optimal skin wound healing relies on tight balance between collagen synthesis and degradation in new tissue formation and remodeling phases. The endocytic receptor uPARAP regulates collagen uptake and intracellular degradation. In this study we examined cutaneous wound repair response of uPARAP null (uPARAP-/-) mice. Full thickness wounds were created on dorsal surface of uPARAP-/- or their wil...
متن کاملThe commonality of cutaneous wound repair and lung injury.
Richard A. Clark, M.D. Soluble mediators, formed blood elements, extracellular matrix (ECM) proteins, and parenchymal cells integrate in dynamic interactive processes to effect normal repair of injured tissue. Unencumbered, these processes follow a specific time sequence. These wound repair events can be temporally grouped into inflammation, tissue formation, and tissue remodeling; however, the...
متن کاملPeriostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair.
The matricellular protein periostin is expressed in the skin. Although periostin has been hypothesized to contribute to dermal homeostasis and repair, this has not been directly tested. To assess the contribution of periostin to dermal healing, 6 mm full-thickness excisional wounds were created in the skin of periostin-knockout and wild-type, sex-matched control mice. In wild-type mice, periost...
متن کاملThe wound repair response controls outcome to cutaneous leishmaniasis.
Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated lmr1, -2, and -3, which exert their effect independently of T cell immune responses. Here, we show that the wound repair response is critically imp...
متن کاملActivation of keratinocyte fibronectin receptor function during cutaneous wound healing.
Keratinocytes freshly isolated from unwounded skin could not attach and spread on fibronectin (FN)-coated culture dishes and could not bind and phagocytose FN-coated beads. These adhesive functions were activated, however, in keratinocytes that were isolated from healing wounds. Moreover, adhesiveness of basal keratinocytes to FN substrata was activated during epidermal cell or explant culture....
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0092660